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Midostaurin (PKC412) | ≥99%(HPLC) | Selleck | PKC inhibitor
Midostaurin (PKC412) | ≥99%(HPLC) | Selleck | PKC inhibitor

The FLT3 inhibitor PKC412 exerts differential cell cycle effects on  leukemic cells depending on the presence of FLT3 mutations | Oncogene
The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations | Oncogene

Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein  kinase C inhibitor, combined with gemcitabine and cisplatin in patients  with non-small-cell lung cancer - Annals of Oncology
Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer - Annals of Oncology

A) Effects of PKC412 inhibition of phospho-FLT3 in MOLM13-S and... |  Download Scientific Diagram
A) Effects of PKC412 inhibition of phospho-FLT3 in MOLM13-S and... | Download Scientific Diagram

Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein  kinase C inhibitor, combined with gemcitabine and cisplatin in patients  with non-small-cell lung cancer - Annals of Oncology
Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer - Annals of Oncology

Alliance -
Alliance -

Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3  inhibitors in acute myeloid leukaemia | Leukemia
Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia | Leukemia

Kinase inhibition by PKC412 prevents epithelial sheet damage in autosomal  dominant epidermolysis bullosa simplex via keratin and cell contact  stabilization - ScienceDirect
Kinase inhibition by PKC412 prevents epithelial sheet damage in autosomal dominant epidermolysis bullosa simplex via keratin and cell contact stabilization - ScienceDirect

Evolving Therapeutic Options for Acute Myeloid Leukemia
Evolving Therapeutic Options for Acute Myeloid Leukemia

FDA grants Breakthrough Therapy status to PKC412
FDA grants Breakthrough Therapy status to PKC412

Frontiers | Combination of Venetoclax and Midostaurin Efficiently  Suppressed Relapsed t(8;21)Acute Myeloid Leukemia With Mutant KIT After  Failure of Venetoclax Plus Azacitidine Treatment
Frontiers | Combination of Venetoclax and Midostaurin Efficiently Suppressed Relapsed t(8;21)Acute Myeloid Leukemia With Mutant KIT After Failure of Venetoclax Plus Azacitidine Treatment

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid  leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain -  ScienceDirect
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain - ScienceDirect

Midostaurin after allogeneic stem cell transplant in patients with  FLT3-internal tandem duplication-positive acute myeloid leukemia | Bone  Marrow Transplantation
Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia | Bone Marrow Transplantation

Figures and data in Overcoming myelosuppression due to synthetic lethal  toxicity for FLT3-targeted acute myeloid leukemia therapy | eLife
Figures and data in Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy | eLife

Cancers | Free Full-Text | Targeted Therapies for the Evolving Molecular  Landscape of Acute Myeloid Leukemia | HTML
Cancers | Free Full-Text | Targeted Therapies for the Evolving Molecular Landscape of Acute Myeloid Leukemia | HTML

Evolving Therapeutic Options for Acute Myeloid Leukemia
Evolving Therapeutic Options for Acute Myeloid Leukemia

Dose–response curves of PKC412 for MOLM13, MOLM14, MV4-11, KOPB-26,... |  Download Scientific Diagram
Dose–response curves of PKC412 for MOLM13, MOLM14, MV4-11, KOPB-26,... | Download Scientific Diagram

CCL5 mediates target‐kinase independent resistance to FLT3 inhibitors in  FLT3‐ITD‐positive AML - Waldeck - 2020 - Molecular Oncology - Wiley Online  Library
CCL5 mediates target‐kinase independent resistance to FLT3 inhibitors in FLT3‐ITD‐positive AML - Waldeck - 2020 - Molecular Oncology - Wiley Online Library

A) Comparison of rate of proliferation of MOLM13-S, MOLM13-R-PKC412... |  Download Scientific Diagram
A) Comparison of rate of proliferation of MOLM13-S, MOLM13-R-PKC412... | Download Scientific Diagram

PDF] Patients with acute myeloid leukemia and an activating mutation in  FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. |  Semantic Scholar
PDF] Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. | Semantic Scholar

Structure-activity relationship between PKC412 analogs and SYK... |  Download Scientific Diagram
Structure-activity relationship between PKC412 analogs and SYK... | Download Scientific Diagram

Midostaurin: a magic bullet that blocks mast cell expansion and activation  - Annals of Oncology
Midostaurin: a magic bullet that blocks mast cell expansion and activation - Annals of Oncology

Synergistic effect of all‑trans retinoic acid in combination with protein  kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia  cells
Synergistic effect of all‑trans retinoic acid in combination with protein kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia cells

Midostaurin (PKC412) | CAS:120685-11-2 | PKC inhibitor | High Purity |  Manufacturer BioCrick
Midostaurin (PKC412) | CAS:120685-11-2 | PKC inhibitor | High Purity | Manufacturer BioCrick

Midostaurin (PKC412) | Multi-targeted Protein Kinase Inhibitor |  MedChemExpress
Midostaurin (PKC412) | Multi-targeted Protein Kinase Inhibitor | MedChemExpress

Inhibition of FLT3-ITD signaling by AG1295 or PKC412 leads to induction...  | Download Scientific Diagram
Inhibition of FLT3-ITD signaling by AG1295 or PKC412 leads to induction... | Download Scientific Diagram